Why the study?
Exercise training ameliorates post-MI cardiac dysfunction, but the underlying mechanisms and functions of exercise-induced cardioprotective factors require further synthesis to offer therapeutic targets.
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Design
Review
Exercise-induced cardioprotective factors, including peptides and non-coding RNAs delivered via extracellular vesicles, offer novel mechanistic insights and potential therapeutic targets for myocardial infarction.
Exercise training has been reported to ameliorate heart dysfunction in both humans and animals after myocardial infarction (MI). Exercise-induced cardioprotective factors have been implicated in mediating cardiac repair under pathological conditions. These protective factors secreted by or enriched in the heart could exert cardioprotective functions in an autocrine or paracrine manner. Extracellular vesicles, especially exosomes, contain key molecules and play an essential role in cell-to-cell communication via delivery of various factors, which may be a novel target to study the mechanism of exercise-induced benefits, besides traditional signaling pathways. This review is designed to demonstrate the function and underlying protective mechanism of exercise-induced cardioprotective factors in MI, with an aim to offer more potential therapeutic targets for MI.
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Guo et al. (2020) studied this question.
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