Describes an improved large-scale synthesis of the broad-spectrum antiviral compound aUY11.
May support expanded preclinical antiviral research; leaves open clinical translation and efficacy testing.
Rigid amphipathic fusion inhibitors (RAFIs), 5-arylethynyl-uracil nucleosides with bulky aryl groups, constitute a class of compounds active against enveloped viruses.1 Derivatives of perylene, a p...
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Chistov et al. (2017) studied this question.
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