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It has been known for more than one hundred years that cells multiply through division. It is however only during the last three decades that it has become possible to identify the molecular mechanisms that regulate cell division, especially the enzyme which literally catalyses mitotic division, MPF (M-phase promoting factor). This chapter reviews the advances in understanding MPF activation during the meiotic cell cycle. Oocytes are arrested at prophase of meiosis I. Resumption of meiosis is called meiotic maturation and is comprised of two consecutive M-phases with no intervening S-phase. Oocyte meiosis then arrests again to await fertilization. We discuss the meiosis-specific modulations in the regulation of MPF related to the release of the prophase meiotic arrest and entry into meiosis I.
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Catherine Jessus (2010) studied this question.
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