Entinostat, a histone deacetylase inhibitor, increases the population of IL-10⁺regulatory B cells to suppress contact hypersensitivity

October 29, 2021BMB ReportsOpen Access

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to investigate how entinostat affects IL-10 production in regulatory B cells to suppress contact hypersensitivity.
In vivo experiments assessed the effect of entinostat on Breg cells and contact hypersensitivity.
Histone deacetylase (HDAC) inhibition was evaluated by measuring IL-10 expression changes in splenic B cells.
Binding interactions of HDAC1 and NF-κB p65 at the IL-10 promoter were analyzed.
Entinostat increased IL-10 expression in Breg cells, enhancing their suppressive function.
Inhibition of HDAC1 binding led to increased NF-κB p65 recruitment and IL-10 production.
Contact hypersensitivity was significantly suppressed in vivo by enhancing Breg cell activity.

We only have this paper's title and publication details.

Answers are grounded in this paper and cite their sources.

Demonstrates increased IL-10 production by Breg cells, suggesting potential for allergy treatment.

No takes yet. Share an insight, caveat, or question.

Min et al. (2021) studied this question.

View Full Paper

Ask AI

Bookmark

Share