Reports of cutaneous photosensitivity to new pharmaceutical agents appear almost every year.¹,²Among drugs causing photosensitivity, nonsteroidal inflammatory drugs (NSAIDs) stand out: first, because they are reported on more frequently than other types of drugs, and second, because of the incongruity that agents designed to inhibit inflammation actually cause light-initiated inflammation. Why are many NSAIDs photosensitizing? Is it just an odd coincidence or is a specific mechanism responsible? Most of the NSAIDs causing photosensitivity are phenylpropionic acid derivatives: benoxaprofen,³⁻⁷carprofen,⁸ketoprofen,⁹tiaprofenic acid,¹⁰and naproxen.¹⁰In this issue of theArchives, Kaidby and Mitchell¹¹extend this list to a new NSAID, nabumetone, in their report on experimentally induced phototoxicity to propionic acid-derivative NSAIDs in volunteers. The cutaneous photosensitivity to NSAIDs appears to be elicited by a phototoxicity mechanism. The response is immediate (within minutes of exposure to ultraviolet [UV] radiation) for benoxaprofen, naproxen,
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I. E. Kocheva (1989) studied this question.