electrically excitable tissue, including neurones.This may be a dosedependent phenomenon, however, the patient usually presenting with the more typical neurological features before a sufficiently toxic concentration is achieved.Additionally the brain of the elderly or "arteriosclerotic" patient may possibly be predisposed to the development of digoxin-induced convulsions; the previous case report described a 72-year-old man.Transient cerebral ischaemic episodes may, therefore, only partially account for the blackouts seen in elderly patients taking digoxin, and we recommend that, even when there is no gross disturbance of cardiac rhythm, the serum digoxin concentration be measured to exclude digoxin neurotoxicity.
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Ian C. Stewart (1982) studied this question.
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