Photosensitivity and Photo-Onycholysis Due to Demethylchlortetracycline

During the past 2 years a new compound, demethylchlortetracycline (Declomycin),*hereafter referred to as DMCT, has found wide clinical usage as an effective broadspectrum antibiotic. Photosensitivity due to this compound has been reported by Falk,¹Morris,²Trafton,³and Fuhrman.4 None of these reactions were associated with nail changes. The incidence of photosensitivity with onycholysis due to medications has been remarkably low and, to our knowledge, restricted to chlortetracycline (Aureomycin). Harris⁵reported 2 cases of "solar dermatitis" occurring after chlortetracycline therapy, and Shaffer et al.⁶noted photosensitivity in 5 patients, 3 of whom had associated nail changes. Jirasek et al.⁷and Krauskoff et al.⁸have also reported nail changes in patients receiving tetracycline derivatives. In this study our observations concerning a group of 108 patients from private practice, who first received DMCT therapy during the early months of 1959, are presented. Some of the