Key result
In overweight healthy middle-aged Japanese men, weight gain of ≥5% significantly accelerated arterial stiffening compared to those without weight gain (annual increase of 21.8 vs 12.5 cm/s/year).
Why the study?
Does weight gain accelerate arterial stiffening in healthy middle-aged Japanese men across different BMI classifications?
Observational (n=2,080)
No
Does weight gain accelerate arterial stiffening in healthy middle-aged Japanese men across different BMI classifications?
Absolute Event Rate: 21.8% vs 12.5%
p-value: p=<0.05
Weight gain significantly accelerates arterial stiffening in overweight middle-aged men, but not in those with normal weight or obesity, highlighting the importance of weight maintenance in this specific group.
May support targeted weight maintenance in overweight middle-aged men; leaves open BMI-specific effects and generalizability beyond this cohort.
The present study was conducted to clarify whether body mass index (BMI [kg/m(2)]) classifications (i.e., without excess weight, overweight, and obese) modify the rate of progression of arterial stiffening, a cardiovascular risk factor associated with weight gain. A 3-year observational study was conducted in 2,080 healthy middle-aged Japanese men (aged 42+/-10 years). Brachial-ankle pulse wave velocity (baPWV) was measured at the beginning and end of the study period. In overweight subjects (30>BMI>or=25), the estimated annual rate of increase of baPWV (ARbaPWV) in subjects with weight gain (>or=5% weight gain; ARbaPWV, 21.8+/-4.4 cm/s/year) was significantly higher than in those without weight gain (<5% weight gain; ARbaPWV, 12.5+/-1.6 cm/s/year), after adjustments for changes in blood pressure and other variables (p<0.05). This change was not observed in subjects without excess weight (BMI<25) or in obese subjects (BMI>or=30). The increase in the ARbaPWV associated with weight gain in the overweight group was also higher than that in the without excess body weight or obese groups. Our study revealed that the BMI classifications modified the annual rate of increase in arterial stiffening associated with weight gain. Weight gain seemed to accelerate arterial stiffening in overweight subjects, but not in subjects without excess weight. The weight gain in overweight subjects seemed to worsen the cardiovascular risk related to arterial stiffness in middle-aged healthy Japanese men. Thus, the prevention of weight gain should be emphasized in overweight subjects.
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Yamada et al. (2008) conducted an observational in Healthy (n=2,080). Weight gain (≥5%) vs. Weight gain <5% was evaluated on Estimated annual rate of increase of brachial-ankle pulse wave velocity (ARbaPWV) in overweight subjects (p=<0.05). In overweight healthy middle-aged Japanese men, weight gain of ≥5% significantly accelerated arterial stiffening compared to those without weight gain (annual increase of 21.8 vs 12.5 cm/s/year).
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