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The integration of smart nanomaterials into pharmaceutics has transformed approaches to disease diagnosis, targeted therapy, and tissue regeneration. These nanoscale materials exhibit unique features such as controlled responsiveness, biocompatibility, and precise site-specific action, offering new possibilities for personalized healthcare. This review provides a comprehensive overview of recent advances in the design and application of functional nanomaterials, including nanoparticle-based drug carriers, responsive hydrogels, and nanostructured scaffolds. Special focus is placed on stimuli-triggered systems that achieve controlled drug release and localized therapeutic effects. In addition, the review explores how these materials enhance diagnostic imaging and support tissue regeneration through adaptive and multifunctional designs. Importantly, this work uniquely integrates stimuli-responsive nanomaterials across therapeutic, imaging, and regenerative domains, providing a unified view of their biomedical potential. The challenges of clinical translation, large-scale synthesis, and regulatory approval are critically analyzed to outline future directions for research and real-world implementation. Overall, this review highlights the pivotal role of smart nanomaterials in advancing modern pharmaceutics toward more effective and patient-centered therapies.
Parvin et al. (Mon,) studied this question.
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