Revisited Upper Reference Limits for Highly Sensitive Cardiac Troponin T in Relation to Age, Sex, and Renal Function

Figures

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  Figure 1. Study population: of 9882 adults, 2460 were excluded due to cardiac diseases, and 1786 were excluded due to abnormal NT-proBNP or HbA1c values. A total of 5636 participants were included in the analysis of hs-cTnT values in relation to sex and renal function (study cohort 2). For the calculation of age-adjusted and sex-adjusted hs-cTnT values, participants with an impaired eGFR were excluded (study cohort 1). CAD: coronary artery disease; HbA1c: hemoglobin A1c; NT-proBNP: amino-terminus pro B-type natriuretic peptide; eGFR: estimated glomerular filtration rate.

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  Figure 2. Age-specific floating median (circles) and 99th percentile (squares) hs-cTnT values in females (red) and males (blue). The ranges of 97th–99.4th hs-cTnT percentiles (smoothed with a window size of +/−10 years per point) are highlighted in light red (females) and light blue (males). Hs-cTnT: highly sensitive troponin T.

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  Figure 3. Floating median hs-cTnT values in relation to serum creatinine (window size of +/−15 μmol/L per point, steps of 10 μmol/L) in females (red curve) and males (blue curve). Increasing serum creatinine values correlate with higher median hs-cTnT concentrations. Hs-cTnT: highly sensitive troponin T.

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  Figure 4. Floating median hs-cTnT values in relation to eGFR (window size of +/−10 mL/min/ 1.73 m2 per point, steps of 3 mL/min/1.73 m2) in females (red curve) and males (blue curve). There is a negative correlation between eGFR and hs-cTnT concentrations. Hs-cTnT: highly sensitive troponin T; eGFR: estimated glomerular filtration rate.

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  Figure 5. Three-dimensional illustration of hs-cTnT values in relation to age and serum creatinine in study cohort 2 in females (left, red dots) and males (right, blue dots). Floating 99th percentiles are displayed as a grey surface area. In addition to age, serum creatinine concentrations show no discernible added effect on hs-cTnT percentiles. Hs-cTnT: highly sensitive troponin T.