Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening

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Key Points

To assess the extent of lung disease in infants with cystic fibrosis diagnosed via newborn screening.
Fifty-seven infants (median age, 3.6 months) with cystic fibrosis underwent bronchoalveolar lavage and chest CT.
A three-slice inspiratory and expiratory CT protocol was used to evaluate lung structure and function.
Infection was found in 12 infants (21.1%), detected bacteria included Staphylococcus aureus (n=4) and Pseudomonas aeruginosa (n=3).
Neutrophilic inflammation was noted at 41.4 x 10(3) cells/ml, constituting 18.7% of total cell count.
Eighty percent of infants (46 out of 57) demonstrated abnormal CT findings, with conditions including bronchial dilatation (n=11, 18.6%) and gas trapping (n=40, 66.7%).

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Examines lung disease in infants with cystic fibrosis, suggesting the need for enhanced early evaluation and treatment strategies.

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Sly et al. (2009) studied this question.

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