Key result
Myocarditis linked to triggering BVACM expression in patients with PKP2 mutations.
This case report suggests that prior myocarditis may act as a trigger for the phenotypic expression of biventricular arrhythmogenic cardiomyopathy in patients with a plakophilin-2 mutation.
Arrhythmogenic-cardiomyopathy (ACM) is an inherited heart disease with right, left, or biventricular (BVACM) involvement based on EKG, imaging, family history, and genetic testing. We present a 64-year-old woman with prior myocarditis and diagnosis of BVACM 29 years later. We propose myocarditis as a promoter of gene expression of plakophilin-2 mutation.
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Johnson et al. (2023) studied this question. Myocarditis is proposed as a trigger for the expression of biventricular arrhythmogenic cardiomyopathy in patients with a plakophilin-2 gene mutation.
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