What question did this study set out to answer?

This research investigates how two consecutive ventricular premature complexes affect repolarization dispersion and the inducibility of arrhythmias.

August 1, 1985Circulation

Dispersion of ventricular repolarization and arrhythmia: study of two consecutive ventricular premature complexes.

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Why the study?

Does the application of two consecutive ventricular premature stimuli (S1S2) increase dispersion of repolarization and induce ventricular arrhythmias in a dog model?

Key Points

This research investigates how two consecutive ventricular premature complexes affect repolarization dispersion and the inducibility of arrhythmias.
Studied 16 dogs under normal conditions and 4 dogs under hypothermia and warm blood perfusion.
Measured dispersion of repolarization from monophasic action potentials on the anterior ventricular surface.
Assessed effects of ventricular premature stimuli (S1 and S1S2) on repolarization parameters.
Control dispersion of repolarization was 29 +/- 7 msec, increasing to 148 +/- 27 msec after S1S2.
In hypothermia, dispersion increased to 149 +/- 29 msec from S1, with no ventricular arrhythmias induced.
Neither S1 nor S1S2 triggered arrhythmias during interventions.

Structured PICO

Does the application of two consecutive ventricular premature stimuli (S1S2) increase dispersion of repolarization and induce ventricular arrhythmias in a dog model?

Population

16 dogs under control conditions and 4 dogs in the presence of an increased dispersion of repolarization during atrial pacing induced by general hypothermia and regional warm blood perfusion

Intervention

Two consecutive ventricular premature stimuli (S1S2) during atrial pacing

Comparator

Atrial pacing alone (control) and single ventricular premature stimulus (S1)

Outcome

Dispersion of repolarization and inducibility of ventricular arrhythmiassurrogate

Two consecutive ventricular premature stimuli significantly increase the dispersion of repolarization compared to a single stimulus, though this alone did not induce ventricular arrhythmias in the control dog model.

Discussion

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Implication

S1S2 markedly increases repolarization dispersion beyond single stimuli in dogs without inducing arrhythmias; leaves open its arrhythmogenic role in humans.

Cite This Study

Kuo et al. (1985) studied this question.

synapsesocial.com/papers/6a214930570f73dd9ac3e48d https://doi.org/10.1161/01.cir.72.2.370

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Implication

S1S2 markedly increases repolarization dispersion beyond single stimuli in dogs without inducing arrhythmias; leaves open its arrhythmogenic role in humans.

Dispersion of ventricular repolarization and arrhythmia: study of two consecutive ventricular premature complexes.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Dispersion of ventricular repolarization and arrhythmia: study of two consecutive ventricular premature complexes.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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