Key result
A liquid chromatography-tandem mass spectrometry method for apixaban determination in human plasma demonstrated high accuracy (96.5% to 102%) and precision (1.21% to 3.21%).
The developed LC-MS/MS method for apixaban determination in human plasma is accurate and precise for pharmacokinetic studies in the Indian population.
Enables reliable apixaban plasma assays for PK research; leaves open routine clinical implementation.
. The inter-day/between-run precision ranged from 1.21% to 3.21%, while the accuracy ranged from 96.5% to 102%. For pharmacokinetics analysis, the validated method was applied. The percentage difference between findings from samples that were reanalyzed and samples that were initially analyzed was within ±20%. With high-quality assay specificity and accuracy in relation to apixaban analysis in human plasma under the experimental conditions used, the method provided is accurate.
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Shaikh et al. (2021) studied this question. Liquid chromatography-tandem mass spectrometry method for apixaban was evaluated on Inter-day/between-run precision and accuracy. A liquid chromatography-tandem mass spectrometry method for apixaban determination in human plasma demonstrated high accuracy (96.5% to 102%) and precision (1.21% to 3.21%).
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