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The normal ontogeny of the bursa of Fabricius is necessary for the successful genesis of antibody-mediated immunity, while the avian thymus appears to control cell-mediated immunity. Regression-regeneration experiments suggest that the thymic-dependent system is better buffered than the bursal-dependent system. A mammalian equivalent of the bursa may exist. Clarification of the mechanism of bursa action is necessary to understand the control of immunoglobulin or antibody production.
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Bruce Glick (1970) studied this question.
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