Key result
Secondary cardiac dysfunction in patients with traumatic brain injury was associated with significantly higher hospital mortality (OR 6.66) compared to those with normal cardiac function.
Why the study?
Cardiac dysfunction has been rarely reported in patients with traumatic brain injury, and its impact on clinical outcomes remained unclear.
Does secondary cardiac dysfunction worsen hospital mortality and length of stay in patients with traumatic brain injury?
Cohort (n=272)
No
Does secondary cardiac dysfunction worsen hospital mortality and length of stay in patients with traumatic brain injury?
Secondary cardiac dysfunction in patients with traumatic brain injury is an independent predictor of increased hospital mortality and prolonged ICU stay.
Answers are grounded in this paper and cite their sources.
May warrant cardiac monitoring in TBI; leaves open whether dysfunction is causal or modifiable.
Purpose: Cardiac dysfunction has been rarely reported in patients with traumatic brain injury (TBI). The study aimed to compare clinical outcomes in patients admitted in intensive care unit (ICU) with normal cardiac function versus cardiac dysfunction after TBI. Moreover, the association of risk factors and hospital mortality ICU or hospital length of stay was investigated. Methods: A retrospective study was conducted from December 2011 to April 2018 on TBI patients admitted without pre-existing cardiac diseases. Patients with TBI were grouped into secondary cardiac dysfunction (n = 112) and normal cardiac function (n = 160) groups according to the presence of abnormal echocardiography after ICU admission. Univariate and multivariate analyses were performed. Results: Elevated BNP and troponin levels were found in the group with cardiac dysfunction. Patients with cardiac dysfunction had significantly higher hospital mortality (16.96% vs. 8.13%), longer ICU length of stay (16.34 vs. 10.99 d) than those without cardiac events. Cardiac dysfunction was an independent predictor of hospital mortality (p < 0.001) and the ICU length of stay (p < 0.001) after adjusting confounders. Risk factors mainly associated with hospital length of stay were age (p = 0.043), GCS score (p < 0.001), and use of mechanical ventilation (p = 0.013). GCS score (p < 0.001) use of vasopressor was related factors associated with ICU length of stay (p = 0.018). Conclusions: Cardiac dysfunction in context of TBI has a negative impact on clinical outcomes, and it is an independent predictor for increasing hospital mortality and longer ICU length of stay.
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Zhang et al. (2021) conducted a cohort in Traumatic Brain Injury (n=272). Secondary cardiac dysfunction vs. Normal cardiac function was evaluated on Hospital mortality (OR 6.660, 95% CI 2.39-18.61, p=<0.001). Secondary cardiac dysfunction in patients with traumatic brain injury was associated with significantly higher hospital mortality (OR 6.66) compared to those with normal cardiac function.
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