Key result
Intravenous trimethaphan successfully simulated acute autonomic failure in healthy subjects, significantly decreasing plasma norepinephrine from 1.1 nmol/L to 0.23 nmol/L (P<.001).
Why the study?
Does intravenous trimethaphan effectively simulate acute autonomic failure in healthy subjects?
Population
7 healthy subjects (4 men, 3 women, aged 32+/-3 years, 68+/-4 kg, 171+/-5 cm)
Comparison
Intravenous trimethaphan to block N-nicotinic… vs Baseline (pre-infusion)
Design
Other
Follow-up
Acute (during infusion)
Authors
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May model acute autonomic failure for research; leaves open validation and clinical translation.
Does intravenous trimethaphan effectively simulate acute autonomic failure in healthy subjects?
Absolute Event Rate: 0.23% vs 1.1%
p-value: p=<.001
Intravenous trimethaphan effectively simulates acute autonomic failure in healthy humans, providing a model to study cardiovascular physiology without confounding baroreflexes.
Jordan et al. (1998) studied Healthy subjects (n=7). Intravenous trimethaphan vs. Baseline was evaluated on Plasma norepinephrine level (nmol/L) (p=<.001). Intravenous trimethaphan successfully simulated acute autonomic failure in healthy subjects, significantly decreasing plasma norepinephrine from 1.1 nmol/L to 0.23 nmol/L (P<.001).
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