Electrocardiographic Predictors of Arrhythmic Death and Total Mortality in the Multicenter Unsustained Tachycardia Trial
Key result
Left ventricular hypertrophy increased the risk of arrhythmic mortality (HR 1.35; 95% CI 1.08-1.69), while left bundle-branch block and conduction delay increased arrhythmic and total mortality by 50%.
Why the study?
Do ECG markers of conduction abnormalities and left ventricular hypertrophy predict arrhythmic death and total mortality in patients with coronary artery disease, depressed left ventricular function, and nonsustained ventricular tachycardia?
Population
n=1638 patients with coronary artery disease, depressed left ventricular function, and nonsustained…
Comparison
Presence of ECG markers of conduction… vs Absence of the respective ECG markers
Design
Cohort
Authors
Discussion
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Implication
In patients with coronary artery disease, depressed left ventricular function, and nonsustained ventricular tachycardia, left bundle-branch block and intraventricular conduction delay are independent predictors of both arrhythmic and total mortality.
Key Points
- This research aims to identify ECG markers that predict arrhythmic and total mortality in patients with coronary artery disease.
- Analyzed ECGs of 1638 participants from the Multicenter Unsustained Tachycardia Trial who did not receive antiarrhythmic therapy.
- Evaluated the prognostic significance of conduction abnormalities and left ventricular hypertrophy post-adjustment for significant factors.
- Left bundle-branch block and intraventricular conduction delay were linked to a 50% increase in the risk of both arrhythmic and total mortality.
- Left ventricular hypertrophy showed a hazard ratio of 1.35 (95% CI: 1.08 to 1.69) for increased arrhythmic mortality, but not total mortality.
Study Design
Type
Cohort (n=1,638)
Multicenter
Yes
Structured PICO
Do ECG markers of conduction abnormalities and left ventricular hypertrophy predict arrhythmic death and total mortality in patients with coronary artery disease, depressed left ventricular function, and nonsustained ventricular tachycardia?
P
Population
1,638 patients with coronary artery disease, depressed left ventricular function, and nonsustained ventricular tachycardia who did not receive antiarrhythmic therapy.
E
Exposure
Presence of ECG markers of conduction abnormalities (left bundle-branch block, intraventricular conduction delay, right bundle-branch block) and left ventricular hypertrophy
C
Comparator
Absence of the respective ECG markers
O
Outcome
Arrhythmic death and total mortalityhard clinical
Main Result
Hazard Ratio: 1.35 (95% CI 1.08–1.69)
In patients with coronary artery disease, depressed left ventricular function, and nonsustained ventricular tachycardia, left bundle-branch block and intraventricular conduction delay are independent predictors of both arrhythmic and total mortality.
Cite This Study
Zimetbaum et al. (2004) conducted a cohort in Coronary artery disease, impaired ventricular function, nonsustained ventricular tachycardia (n=1,638). ECG markers of conduction abnormalities and left ventricular hypertrophy vs. Absence of these ECG markers was evaluated on Arrhythmic death and total mortality (HR 1.35, 95% CI 1.08 to 1.69). Left ventricular hypertrophy increased the risk of arrhythmic mortality (HR 1.35; 95% CI 1.08-1.69), while left bundle-branch block and conduction delay increased arrhythmic and total mortality by 50%.