Key result
Patients with multiple sclerosis show substantial autonomic, pulmonary, and cardiovascular impairments versus healthy controls.
Why the study?
The study was conducted to determine the extent of autonomic dysfunction and pulmonary and cardiovascular impairments at rest and during physical exercise in people with multiple sclerosis compared to healthy controls.
Do people with multiple sclerosis have impaired autonomic, pulmonary, and cardiovascular function at rest and during exercise compared to healthy controls?
Meta-Analysis
Do people with multiple sclerosis have impaired autonomic, pulmonary, and cardiovascular function at rest and during exercise compared to healthy controls?
People with multiple sclerosis exhibit significant autonomic, pulmonary, and cardiovascular impairments at rest and during exercise, which should be considered in their clinical management.
Answers are grounded in this paper and cite their sources.
Merits consideration in multiple sclerosis evaluation; confirms impairments but leaves open intervention effects.
Abstract Purpose The purpose of the present review was to determine the extent of autonomic dysfunction as well as pulmonary and cardiovascular impairments at rest and during physical exercise in people with multiple sclerosis (pwMS) compared to healthy controls. Method A comprehensive literature review was conducted using PubMed and Embase databases. Relevant absolute mean±SD values along with sample sizes for pwMS and healthy controls were extracted in addition to selected participant characteristics and test conditions. Further quantitative analyses were conducted using Cohen's d for effect size (ES) via standardized mean difference (ESSMD) and absolute mean difference (ESMD). The Cochrane Q test was quantified by I² statistics for heterogeneity. Sensitivity analyses were performed to assess robustness of results. Results The literature search yielded 1323 results, of which 45 were included in the meta-analysis. Data analyses revealed substantial autonomic dysfunction as well as substantially impaired pulmonary and cardiovascular function both at rest and during exercise in pwMS when compared to healthy controls. The findings suggested that autonomic dysfunction in pwMS consists of decreased parasympathetic activity in addition to sympathetic hypo-reactivity. Results further indicated that reduced pulmonary and cardiovascular function may in part be attributed to autonomic dysfunction in addition to physical deconditioning of pwMS. Conclusion pwMS exhibits substantial autonomic dysfunction compared to healthy controls. In addition, pwMS show pulmonary and cardiovascular impairments both during resting and exercising conditions. The present review highlights important impairments that should be considered in the clinical management of pwMS.
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Jungersen et al. (2025) conducted a meta-analysis in Multiple sclerosis. Multiple sclerosis vs. Healthy controls was evaluated on Autonomic, pulmonary and cardiovascular function at rest and during physical exercise. People with multiple sclerosis exhibit substantial autonomic dysfunction, pulmonary, and cardiovascular impairments at rest and during exercise compared to healthy controls across 45 studies.
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