Key result
Total physical activity was inversely associated with incident atrial fibrillation in women, demonstrating a 93% risk reduction (HR 0.07) for those engaging in 174-233 MET-hr/wk compared to the lowest activity quartile.
Why the study?
Does higher physical activity or walking pace reduce the incidence of atrial fibrillation in men and women without baseline cardiovascular disease?
Cohort (n=6,487)
Yes
Does higher physical activity or walking pace reduce the incidence of atrial fibrillation in men and women without baseline cardiovascular disease?
Hazard Ratio: 0.07 (95% CI 0.01–0.56)
Higher total physical activity is associated with a reduced risk of incident atrial fibrillation in women, but not men, highlighting potential sex-specific cardiac adaptations to exercise.
Hypothesis-generating for sex-specific AF prevention via activity in women; does not yet support practice changes or extension to men.
OBJECTIVES: Although the effect of physical activity (PA) on the incidence of atrial fibrillation (AF) has been studied, contradictory results have been reported. Such discrepancies may reflect the different effects of various types of PA upon AF, as well as gender interactions. Therefore, we aimed to evaluate the associations of PA types (total, moderate/vigorous, and intentional), as well as walking pace, with AF risk in men and women. METHODS: Using the Multi-Ethnic Study of Atherosclerosis Typical Week Physical Activity Survey, 3 PA measures and walking pace were calculated among 6,487 men and women aged 45-84 years. The incidence of AF over approximately 11 years of follow-up was ascertained. The association of each PA measure and walking pace with AF incidence was estimated using multivariable Cox proportional hazard models. An extended Cox model with Heaviside functions (hv) of time was used to estimate the effects of time-varying covariates. RESULTS: During 11 years of follow-up (49,557 person-years), 242 new AF cases occurred. The incidence rate of AF was 48.83 per 10,000 person-years. The proportional hazard (PH) assumption for total PA among women was not met; hence, we used the hv to calculate the hazard ratio. Total PA in women in the hv2 analysis was negatively associated with AF in all 3 models, although for hv1 no significant association was observed. The PH assumption for walking pace among men was not met, and none of the hv showed a statistically significant association between walking pace and AF in men. CONCLUSIONS: These results suggest that PA is inversely associated with AF in women.
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Mokhayeri et al. (2017) conducted a cohort in Atrial fibrillation (n=6,487). Physical activity vs. Lowest quartile of physical activity (5-122 MET-hr/wk) was evaluated on Incidence of atrial fibrillation (HR 0.07, 95% CI 0.01-0.56). Total physical activity was inversely associated with incident atrial fibrillation in women, demonstrating a 93% risk reduction (HR 0.07) for those engaging in 174-233 MET-hr/wk compared to the lowest activity quartile.
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