Key result
An atypical waking cortisol pattern in male police officers predicted a larger 7-year mean decline in flow-mediated dilation compared with the highest tertile (-2.56 vs -0.89; P=0.0087).
Why the study?
Does an atypical cortisol awakening response predict worsening of brachial artery flow-mediated dilation in police officers?
Cohort (n=172)
Does an atypical cortisol awakening response predict worsening of brachial artery flow-mediated dilation in police officers?
Absolute Event Rate: -2.56% vs -0.89%
p-value: p=0.0087
An atypical waking cortisol pattern (lowest AUCI tertile) predicts worsening endothelial function (FMD%) over 7 years in male police officers.
OBJECTIVE: To examine the association of the cortisol awakening response (CAR) with change in brachial artery flow-mediated dilation (FMD%) in police officers over a 7-year period. METHODS: Baseline CAR was obtained from four saliva samples taken 15 minutes apart immediately after awakening. Analysis of covariance was used to compare the change in FMD% (FMD%Follow-up-FMD%Baseline) across tertiles of area under the cortisol curve with respect to increase (AUCI). Regression analysis was use to assess trend. RESULTS: Officers (n = 172; 81% men) had a mean ± SD age of 41 ± 7.6 years. Men in the lowest AUCI tertile (ie, atypical waking cortisol pattern) had a significantly larger 7-year mean decline in FMD% (mean ± SE: -2.56 ± 0.64) compared with men in the highest tertile (-0.89 ± 0.69) (P = 0.0087). CONCLUSIONS: An awakening cortisol AUCI predicted worsening of FMD% approximately 7 years later among male officers.
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Violanti et al. (2018) conducted a cohort in Subclinical cardiovascular disease (n=172). Lowest AUCI tertile (atypical waking cortisol pattern) vs. Highest AUCI tertile was evaluated on Change in brachial artery flow-mediated dilation (FMD%) (p=0.0087). An atypical waking cortisol pattern in male police officers predicted a larger 7-year mean decline in flow-mediated dilation compared with the highest tertile (-2.56 vs -0.89; P=0.0087).
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