Key result
In silico epitope prediction and VP1 modelling of Foot-and-Mouth Disease Virus serotype SAT 2 identified conserved regions as candidates for region-tailored vaccine design in East Africa.
Why the study?
Foot and Mouth Disease Virus serotypes lack cross-protection, while inactivated vaccines pose safety concerns and confer relatively short immunity.
In silico prediction of epitopes for FMDV serotype SAT 2 provides structural candidates for region-tailored vaccine design in East Africa.
Provides in silico candidates for East African FMDV SAT2 vaccines; leaves open in vivo validation before any clinical use.
Foot and Mouth Disease Virus has seven distinct, geographically localized, serotypes and a vaccination targeting one serotype does not confer immunity against another serotype. The use of inactivated vaccines is not safe and confers an immunity with a relatively shorter time. Using the VP1 sequences isolated in East Africa, we have predicted epitopes able to induce humoral and cell-mediated immunity in cattle. The Wu-Kabat variability index calculated in this study reflects the variable, including the known GH loop, and conserved regions, with the latter being good candidates for region-tailored vaccine design. Furthermore, we modelled the identified epitopes on a 3D model (PDB ID:5aca) to represent the epitopes structurally. This study can be used for in vitro and in vivo experiments.
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Udahemuka et al. (2021) studied Foot and Mouth Disease. In silico epitope prediction and VP1 modelling was evaluated on Predicted epitopes and Wu-Kabat variability index. In silico epitope prediction and VP1 modelling of Foot-and-Mouth Disease Virus serotype SAT 2 identified conserved regions as candidates for region-tailored vaccine design in East Africa.
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