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Introduction Discovery of Fru-2,6-P2 Regulation of Enzyme Activities by Fru-2,6-P2 6-Phosphofructo 2-Kinase and Fructose 2,6-Bisphosphatase Integration of Fru-2,6-P2 in Metabolic Regulation Conclusions: Fru-2,6-P2, a Glycolytic Signal
Emile Van Schaftingen (1987) studied this question.