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February 1, 1975Proceedings of the National Academy of Sciences158 citationsOpen Access

X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.

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CTC. C. TsaiSJS C JainHSHenry M. Sobell

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Abstract

We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.

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Cite This Study

Tsai et al. (1975) studied this question.

synapsesocial.com/papers/6a2171445c0c8498e25805f5https://doi.org/10.1073/pnas.72.2.628
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ethidium bromide–dinucleotide complexes. Evidence for intercalation and sequence preferences in binding to double‐stranded nucleic acids1975 · 100 citations
  2. 2Structural considerations in the interaction of DNA and acridines1961 · 2,248 citations
  3. 3The Synthesis and Enzymatic Polymerization of Nucleotides Containing Mercury: Potential Tools for Nucleic Acid Sequencing and Structural Analysis1973 · 102 citations
  4. 4Determination of Absolute from Relative X-Ray Intensity Data1942 · 426 citations
  5. 5THE STRUCTURE OF THE DNA-ACRIDINE COMPLEX1963 · 721 citations