The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety

Significance Animals constantly monitor their internal energy levels and modify their eating and foraging behavior as required. Our work defines a role for the ETS-5 transcription factor in the control of body fat levels and thereby the activity of animals. We have defined the responses controlled by ETS-5 at the genetic, cellular, and organismal levels and identified how ETS-5 interacts with known pathways that regulate food-regulated behavioral states. These findings provide insight into how fat levels are regulated and how satiety controls organismal activity.