Key result
Long-term continuous and moderate-to-vigorous exercise promote the greatest cardiac angiogenesis.
Why the study?
This systematic review aimed to analyse the effects of different exercise intensities and durations in cardiac angiogenesis regulation between healthy animal and human studies.
Do different exercise intensities and durations improve cardiac angiogenesis regulation in healthy populations?
Systematic Review (n=16)
Do different exercise intensities and durations improve cardiac angiogenesis regulation in healthy populations?
Long-term continuous exercise at moderate to vigorous intensity appears most effective for promoting cardiac angiogenesis in healthy populations.
Supports prioritizing long-term continuous moderate-vigorous exercise for cardiac health; extends mixed human-animal evidence but requires prospective human validation.
Numerous studies showed the exercise intensity and exercise duration involved in the pathways of angiogenesis biomarkers expression. The aim of this systematic review was to analyse the effects of different exercise intensities and exercise duration in cardiac angiogenesis regulation between healthy animal studies and human studies. The research databases used in this systematic review, including MEDLINE and Cochrane Library, within the last 6 years from 2018 to 2023 and published in English. Before the study selection, the study duplication was detected by Zotero Reference Manager ® and then removed. The related studies examined and selected with rayyan.ai ® website using a ‘blind-on’ mode to ensure eligibility. The eligible studies were assessed by the SYRCLE’s risk of bias tool and Risk of Bias Tool 2.0. A total of 16 studies were included, consisting of 5 animal studies or in vivo or experimental studies and 11 human studies or clinical trials. The studies then grouped in 3 durations of exercise, that was short-term, long-term term-intermittent, and long-term-continuous exercise. The most significant duration and intensity were found in long-term-continuous exercise and moderate to vigorous intensity exercise. Further research needs to explain the other factors of exercise that influence cardiac angiogenesis, such as the frequency and the type of exercise both in humans and animals to determine the most effective exercise program for a healthy population, as a potential prevention from the cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Fitrianti et al. (2025) conducted a systematic review in Healthy (n=16). Exercise was evaluated on Cardiac angiogenesis regulation. Long-term-continuous exercise and moderate to vigorous intensity exercise demonstrated the most significant effects on cardiac angiogenesis across 16 human and animal studies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: