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January 1, 2018Annals of Tropical Pathology

Hydroxyurea: Modifier of pathophysiology in sickle cell anemia

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Authors

AAAkinsegun AkinbamiEUEbele UcheADAdedoyin Dosunmu

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Overview

Review discusses hydroxyurea's effects on sickle cell anemia severity and treatment protocols.

Key Points

  • This review aims to evaluate the role of hydroxyurea in modifying the pathophysiology and clinical outcomes of sickle cell anemia.
  • Provides a comprehensive review of hydroxyurea's mode of action, clinical indications, and treatment protocols.
  • Explores monitoring and management of hydroxyurea therapy, including toxicity assessments.
  • Discusses clinical variations in sickle cell anemia and the rationale for hydroxyurea use.
  • Hydroxyurea has demonstrated improvement in clinical outcomes for moderate-to-severe sickle cell anemia patients.
  • The therapy's effectiveness varies based on patient-specific clinical severity and treatment initiation timing.
  • Recommendations for hydroxyurea use are reinforced based on its potential benefits and safety in selected patients.

Cite This Study

Akinbami et al. (2018) studied this question.

synapsesocial.com/papers/6a218294ad8d6edcc457db55https://doi.org/10.4103/atp.atp_31_17
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mortality in sickle cell patients on hydroxyurea therapy2004 · 100 citations
  2. 2Effective control of sickle cell disease with hydroxyurea therapy2010 · 36 citations
  3. 3Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.1984 · 540 citations
  4. 4Acute phase reactants and severity of homozygous sickle cell disease1993 · 92 citations
  5. 5Clinical diversity of sickle cell anemia: Genetic and cellular modulation of disease severity1983 · 74 citations