Key result
Subclinical hypothyroidism was associated with significantly lower aortic distensibility and higher aortic stiffness index compared to healthy controls, indicating impaired ascending aorta elasticity.
Why the study?
Does subclinical hypothyroidism impair the elasticity properties of the ascending aorta compared to healthy controls?
Case-Control (n=91)
Does subclinical hypothyroidism impair the elasticity properties of the ascending aorta compared to healthy controls?
Subclinical hypothyroidism is associated with impaired elasticity of the ascending aorta, which can be reproducibly evaluated using tissue Doppler imaging.
Subclinical hypothyroidism may impair aortic elasticity; case-control data leave open causal inference and clinical implications.
OBJECTIVE: We aimed to investigate whether aortic elastic properties were affected in subclinical hypothyroidism (SCH) by using tissue Doppler imaging (TDI). SUBJECTS AND METHODS: Forty-three patients with newly diagnosed SCH and forty-eight healthy controls were included to the study. Systolic and diastolic diameters of the ascending aorta were measured by M-mode transthoracic echocardiography, and the upper wall velocities of ascending aorta and mitral annulus velocities were measured by TDI. Aortic stiffness index (ASI) and aortic distensibility were computed using the formulas accepted in literature. RESULTS: The clinical and demographic features of both groups were comparable. Aortic distensibility was significantly lower, and ASI was significantly higher in SCH patients than in controls. Systolic aortic upper wall velocity (Sao) was also significantly lower in SCH patients. Early (Eao) and late diastolic aortic upper wall (Aao) velocities did not differ between the two groups. Mitral annulus (Sm, Em, and Am) velocities were also similar between the groups. Sao was negatively correlated with ASI, and positively correlated with aortic distensibility. TSH level was positively correlated with ASI, total cholesterol and low-density lipoprotein-cholesterol, and negatively correlated with aortic distensibility and Sao. CONCLUSIONS: In this study, our results showed that SCH is associated with impaired elasticity of the ascending aorta. Elastic properties of the ascending aorta can be directly evaluated by the reproducibly measurement of the upper wall movements of the ascending aorta by TDI in SCH patients.
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Yurtdaş et al. (2013) conducted a case-control in Subclinical hypothyroidism (n=91). Subclinical hypothyroidism vs. Healthy controls was evaluated on Aortic elastic properties (aortic stiffness index and aortic distensibility). Subclinical hypothyroidism was associated with significantly lower aortic distensibility and higher aortic stiffness index compared to healthy controls, indicating impaired ascending aorta elasticity.
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