Cine MR imaging successfully quantified regurgitant fraction, which was 4% in healthy subjects, 12% in mild, 35% in moderate, and 63% in severe regurgitation.
Cross-Sectional (n=33)
Does cine MR imaging accurately quantify regurgitant fraction in patients with mitral or aortic regurgitation compared to standard modalities?
Cine MR imaging is a feasible method for quantifying regurgitant fraction in patients with mitral or aortic regurgitation, with values that correlate with disease severity.
A new, rapid magnetic resonance (MR) imaging method, cine MR imaging, was used to determine the regurgitant fraction (RF) in patients with left-sided regurgitant lesions. Right and left ventricular stroke volumes were determined with cine MR imaging and a modified Simpson formula in ten healthy volunteers and 23 patients known to have either predominant mitral (n = 17) or aortic (n = 6) regurgitation. RFs evaluated at cine MR imaging were compared in healthy persons and patients with mild, moderate, or severe regurgitation demonstrated at angiography (n = 10) and Doppler echocardiography (n = 13). Cine MR imaging depicted regurgitant blood flow in all 29 regurgitant lesions in 23 patients as areas of low signal intensity within the regurgitant chamber. The RF was 4% +/- 7% in healthy subjects and 12% +/- 12% in those with mild, 35% +/- 14% in those with moderate, and 63% +/- 5% in those with severe regurgitation. The RFs determined by two observers were similar.
Sechtem et al. (1988) conducted a cross-sectional in Mitral or aortic regurgitation (n=33). Cine MR imaging vs. Healthy volunteers and reference imaging (angiography/Doppler echocardiography) was evaluated on Regurgitant fraction (RF). Cine MR imaging successfully quantified regurgitant fraction, which was 4% in healthy subjects, 12% in mild, 35% in moderate, and 63% in severe regurgitation.