Key result
Non-alcoholic fatty liver disease was not significantly associated with increased carotid intima-media thickness compared to subjects without NAFLD (34.5% vs 19.1%; P=0.063).
Why the study?
Data were limited on the association between NAFLD and advanced fibrosis assessed using Fibroscan with carotid intima-media thickness in the general population.
Is non-alcoholic fatty liver disease (NAFLD) or advanced fibrosis associated with increased carotid intima-media thickness (CIMT) in a multiethnic Asian community?
Cross-Sectional (n=251)
No
Is non-alcoholic fatty liver disease (NAFLD) or advanced fibrosis associated with increased carotid intima-media thickness (CIMT) in a multiethnic Asian community?
In a Malaysian screening cohort, NAFLD and advanced liver fibrosis assessed by transient elastography did not show a statistically significant association with increased carotid intima-media thickness, though a trend was observed for NAFLD.
Should not yet change cardiovascular risk assessment in NAFLD; leaves open any subclinical atherosclerosis link in multiethnic Asians.
Background and Aim There is not much data on the association between non‐alcoholic fatty liver disease (NAFLD) and advanced fibrosis assessed using Fibroscan with carotid intima‐media thickness (CIMT) in the general population. The objective of this study was to evaluate the association between NAFLD and advanced fibrosis, as diagnosed by Fibroscan, with an increased CIMT in the Malaysian population. Methods A cross‐sectional study of government officers and their family members attending a health screening at a public healthcare facility was conducted. All subjects underwent clinical evaluation, biochemical testing, anthropometry, ultrasound carotid Doppler, and Fibroscan examination. Results Data for 251 subjects were analyzed (mean age 47.1 ± 12.4 years, 74.1% male). Prevalence of NAFLD and advanced fibrosis were 57.4 and 17.5%, respectively. Independent factors associated with NAFLD were waist circumference (odds ratio [OR] = 1.077, 95% confidence interval [CI] 1.038–1.118, P < 0.001) and serum alanine aminotransferase (ALT) (OR = 1.039, 95% CI 1.005–1.074, P = 0.024). Independent factors associated with advanced fibrosis were male gender (OR = 4.847, 95% CI 1.369–17.155, P = 0.014) and serum aspartate aminotransferase (AST) (OR = 1.057, 95% CI 1.003–1.113, P = 0.036). Prevalence of increased CIMT was 29.0%. Independent factor associated with increased CIMT was older age (OR = 1.146, 95% CI 1.067–1.231, P < 0.001). Of the subjects, 34.5% with NAFLD had increased CIMT compared to 19.1% of the subjects without NAFLD ( P = 0.063). Advanced fibrosis was not associated with increased CIMT. Conclusions Prevalence of NAFLD, advanced liver fibrosis, and increased CIMT were high. NAFLD and advanced liver fibrosis appeared not to be associated with increased CIMT. However, a larger sample size is needed to demonstrate whether there is any association.
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Tan et al. (2018) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) (n=251). Non-alcoholic fatty liver disease (NAFLD) vs. Without NAFLD was evaluated on Increased carotid intima-media thickness (CIMT) (p=0.063). Non-alcoholic fatty liver disease was not significantly associated with increased carotid intima-media thickness compared to subjects without NAFLD (34.5% vs 19.1%; P=0.063).
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