Key result
Hemoglobin ≥11 g/dL linked to ~60% lower pulmonary hypertension risk in hemodialysis patients, alongside higher albumin.
Why the study?
The pathogenesis of pulmonary hypertension in hemodialysis patients is unclear, and malnutrition may be linked to impaired pulmonary function in this population.
Cross-Sectional (n=80)
No
Odds Ratio: 0.4 (95% CI 0.218–0.735)
p-value: p=0.003
Lower levels of hemoglobin and albumin are significantly associated with a higher incidence of pulmonary hypertension in hemodialysis patients, suggesting a link between malnutrition/anemia and pulmonary vascular changes.
Does not yet support targeting hemoglobin or albumin to reduce pulmonary hypertension in hemodialysis; hypothesis-generating observation requiring prospective confirmation.
Background: The prevalence of pulmonary hypertension (PH) is reported between 17% and 56% in hemodialysis patients. The pathogenesis of PH in hemodialysis patients is still unclear. Malnutrition may be associated with impaired pulmonary function in hemodialysis patients. Objectives: The present study aimed to investigate the association between PH and nutritional and biochemical markers in hemodialysis patients. Methods: In this cross-sectional study, 80 patients undergoing hemodialysis at the Kowsar Medical Center, Semnan, Iran, from 1 March 2016 to 31 August 2016 were enrolled by complete enumeration. Pulmonary artery pressure was determined by echocardiography between hemodialysis sessions. Arm circumference, triceps fat mass, and body mass index (BMI) were determined. Other laboratory tests included transferrin, serum albumin, cholesterol, triglyceride, and hemoglobin. The source of receiving protein was recorded in a questionnaire. The data were analyzed by the chi-square test and logistic regression analysis at a significance level of less than 0.05. Results: Pulmonary hypertension ( > 25 mmHg) was found in 32 (40%) of the 80 patients studied. The mean of pulmonary pressure in patients with PH was 34.66 ± 5.6 mmHg compared to 16.85 ± 3.7 mmHg in patients without PH. Age, gender, arm circumference, frequency of dialysis per year, and serum levels of albumin, transferrin, triglyceride, and total cholesterol were not significantly different between patients with and without PH. There was a significant difference in the mean hemoglobin level between patients with and without PH (P = 0.003). The likelihood of developing PH was reduced by 0.3 in those with hemoglobin ≥ 11 g/dL compared to patients with hemoglobin levels below 11 g/dL (OR = 0.400, P = 0.003). The likelihood of developing PH in patients with albumin ≥ 3.8 g/L decreased by 0.126 compared to those with albumin less than 3.8 (OR = 0.126, P = 0.003). Conclusions: The results of our study indicated a higher incidence of PH in patients with lower levels of hemoglobin and albumin. So, patients undergoing hemodialysis are recommended to be regularly screened for these two variables.
No takes yet. Share an insight, caveat, or question.
Eskandarian et al. (2023) conducted a cross-sectional in End-Stage Renal Disease on Hemodialysis (n=80). Hemoglobin ≥ 11 g/dL vs. Hemoglobin < 11 g/dL was evaluated on Pulmonary hypertension (OR 0.400, 95% CI 0.218-0.735, p=0.003). Hemoglobin levels ≥ 11 g/dL (OR 0.400) and albumin levels ≥ 3.8 g/L (OR 0.126) were associated with a significantly lower likelihood of pulmonary hypertension in hemodialysis patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: