Key result
Novel cardiac biomarkers, including markers of ischemia, plaque inflammation, and platelet activity, offer potential new diagnostic pathways for evaluating patients with suspected acute coronary syndromes.
Why the study?
Do novel cardiac biomarkers improve the evaluation of patients with suspected acute coronary syndromes compared to traditional necrosis markers?
Do novel cardiac biomarkers improve the evaluation of patients with suspected acute coronary syndromes compared to traditional necrosis markers?
Novel biomarkers reflecting ischemia, plaque inflammation, and platelet activity may enhance the early evaluation of suspected acute coronary syndromes before myocyte necrosis occurs.
May aid pre-necrosis ACS evaluation; leaves open superiority to troponin pending prospective trials.
At present, for the evaluation of patients with suspected acute coronary syndromes (ACS), currently available cardiac biomarkers depend on the presence of myocyte necrosis or left ventricular dysfunction in order to be diagnostic. With a better understanding of the pathophysiology that underlies the ACS has come a wide variety of candidate cardiac biomarkers, whose ability to detect the pathophysiologic processes involved in ACS may represent a step forward for the practicing clinician. Included among these novel biomarkers are markers of myocardial ischemia in the absence of necrosis (ischemia modified albumin and free fatty acids), markers of plaque inflammation and/or instability (myeloperoxidase, pregnancy-associated placental protein-A, whole blood choline, lipoprotein-associated phospholipase A2), as well as markers of platelet activity (soluble CD40 ligand). The potential role of these novel markers in the evaluation of patients with suspected ACS will be reviewed.
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Martinez et al. (2006) conducted a review in Suspected acute coronary syndromes (ACS). Novel cardiac biomarkers was evaluated. Novel cardiac biomarkers, including markers of ischemia, plaque inflammation, and platelet activity, offer potential new diagnostic pathways for evaluating patients with suspected acute coronary syndromes.
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