Cytokine Receptors in Congenital Hematopoietic Disease

Hematopoietic growth factors promote both growth and differentiation of blood cells1,2. These factors activate specific hematopoietic growth factor receptors that are expressed on the surface of blood progenitor cells of the bone marrow. The past decade has witnessed the identification and cloning of several genes for hematopoietic growth factors and growth factor receptors. The availability of the complementary DNA encoding these polypeptides has provided tools for understanding the normal process of blood-cell production and the abnormal processes of leukemia and other diseases in humans.Hematopoietic Growth FactorsThe identification of hematopoietic growth factors was made possible primarily by . . .