What question did this study set out to answer?

To examine the interaction of ceruloplasmin and ionic copper and its role in regulating copper metabolism in vivo.

The Incorporation of Copper Into Ceruloplasmin in Vivo: Studies With Copper64 and Copper67*

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To examine the interaction of ceruloplasmin and ionic copper and its role in regulating copper metabolism in vivo.
Investigated ceruloplasmin copper exchange in patients with Wilson's disease with no ceruloplasmin synthesis.
Measured the half-life of ceruloplasmin in individuals with Wilson's disease versus normal individuals.
Studied ionic copper incorporation into ceruloplasmin in a participant with normal copper metabolism.
In Wilson's disease patients, minimal exchange of ceruloplasmin copper was observed, indicating impaired copper regulation.
Half-life analysis revealed differences in ceruloplasmin catabolism between Wilson's disease patients and healthy individuals.
Normal ionic copper incorporation into ceruloplasmin was confirmed in individuals with typical copper metabolism.

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Randomized trial investigates copper incorporation into ceruloplasmin in Wilson’s disease, suggesting a role in copper regulation.

Sternlieb et al. (1961) studied this question.

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