Key result
Persistent pulmonary vein isolation is linked to a ~41 percentage-point higher rate of notched P-wave disappearance.
Why the study?
Mechanisms involved in P-wave changes after catheter ablation for AF are uncertain, and this study evaluated the relationship between P-wave morphology changes and PV reconnection.
Do changes in P-wave duration and morphology on surface ECG reflect successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation?
Cohort (n=182)
No
Do changes in P-wave duration and morphology on surface ECG reflect successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation?
Reverse dynamics of P-wave duration and the disappearance of notched P waves on standard ECG can serve as noninvasive markers of durable pulmonary vein isolation after catheter ablation.
Answers are grounded in this paper and cite their sources.
Notched P-wave disappearance was associated with absent PV reconnection; hypothesis-generating for ECG monitoring, prospective validation required.
BACKGROUND: The mechanisms involved in changes in P wave following catheter ablation for atrial fibrillation (AF) are uncertain. This study aimed to assess the relationship between changes in P-wave morphology and pulmonary vein (PV) reconnection following ablation by the assessment of 12-lead surface electrocardiogram and signal-averaged electrocardiogram. METHODS: This retrospective study included 115 consecutive patients with paroxysmal AF that underwent repeat ablation for recurrence following initial ablation. We investigated changes in P-wave morphology between baseline and repeat procedure in patients with and without PV reconnection. The study also included as validation group without recurrence (n = 67) following initial ablation. RESULTS: The maximum P-wave duration (PWD) was significantly decreased from baseline to just after the procedure in all groups. However, for the PV reconnection group (n = 100), the maximum PWD was significantly increased again at the repeat procedure. In contrast, the maximum PWD was significantly reduced between baseline and repeat procedure in the non-PV reconnection group (n = 15). The signal-averaged PWD was significantly decreased from baseline to repeat procedure in the non-PV reconnection group, but, conversely, was increased in the PV reconnection group. In the non-PV reconnection group, the disappearance of notched P wave was detected in 8 of 15 patients (53%), which was significantly higher than in other groups (p = .001). A new or delayed notched P wave was identified in the PV reconnection group only. These results were confirmed in the validation group. CONCLUSIONS: The reverse dynamics of PWD after initial shortening directly following ablation were significantly associated with PV reconnection.
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Yanagisawa et al. (2019) conducted a cohort in Paroxysmal atrial fibrillation (n=182). Absence of pulmonary vein (PV) reconnection vs. Pulmonary vein (PV) reconnection was evaluated on Disappearance of notched P wave on electrocardiogram (p=0.001). The disappearance of a notched P wave between baseline and repeat ablation was significantly more frequent in patients without pulmonary vein reconnection compared to those with reconnection (53% vs. 12%, p=0.001).
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