Population
Mechanosensitive channel of large conductance MscL from Escherichia coli reconstituted into sealed vesicles
Comparison
Addition of anionic lipids vs Phosphatidylcholine lipid environment
Design
Preclinical
Authors
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Lipid effects on MscL gating in animal models are hypothesis-generating; leaves open relevance to human cardiac ion channels.
Anionic phospholipids modulate the rate and extent of flux through the mechanosensitive channel MscL by affecting transition states between closed, fully open, and subconductance states.
Powl et al. (2008) studied this question.
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