The development of a photochemical bromination/alkylation sequence as part of a continuous process for the synthesis of an intermediate en route to AMG 423 is discussed. Highlights of this continuous process include a significant reduction in reaction time and the elimination of aqueous waste streams. Also discussed are mechanistic and kinetic studies offering insights into notable features of the photochemical bromination.
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Quasdorf et al. (2022) studied this question.
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