Primer Requirement and Template Specificity of the DNA Polymerase of RNA Tumor Viruses
Population
DNA polymerases found in the virions of avian myeloblastosis virus and mouse leukemia virus
Comparison
Addition of a short complementary… vs Polydeoxyribonucleotide templates
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Primer-dependent RNA preference in viral polymerases informs retroviral mechanisms; leaves open human therapeutic translation.
Structured PICO
P
Population
DNA polymerases found in the virions of avian myeloblastosis virus and mouse leukemia virus
I
Intervention
Addition of a short complementary oligodeoxyribonucleotide primer to polyribonucleotide templates
C
Comparator
Polydeoxyribonucleotide templates
O
Outcome
Synthesis of complementary polydeoxyribonucleotide
DNA polymerases of RNA tumor viruses require a primer for activity and prefer polyribonucleotides over polydeoxyribonucleotides as templates.
Cite This Study
Baltimore et al. (1971) studied this question.