Primer Requirement and Template Specificity of the DNA Polymerase of RNA Tumor Viruses

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Structured PICO

Population

DNA polymerases found in the virions of avian myeloblastosis virus and mouse leukemia virus

Intervention

Addition of a short complementary oligodeoxyribonucleotide primer to polyribonucleotide templates

Comparator

Polydeoxyribonucleotide templates

Outcome

Synthesis of complementary polydeoxyribonucleotide

DNA polymerases of RNA tumor viruses require a primer for activity and prefer polyribonucleotides over polydeoxyribonucleotides as templates.

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Primer-dependent RNA preference in viral polymerases informs retroviral mechanisms; leaves open human therapeutic translation.

Baltimore et al. (1971) studied this question.

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