Synthesis, Physicochemical and Antioxidant Properties of Some Metal(ii) Complexes of Mixed Drugs, Aspirin and Nicotinamide.

The Drugs, Aspirin (HL) and Nicotinamide (HL3), and their mixed metal(II) complexes were synthesized and isolated as [M(HL)(HL3)X2], where M = Fe, Co, Ni, Cu, Zn; X = Cl-/SO42-. These complexes were characterized by spectroscopic techniques (IR & UV-Visible), percentage metal, molar conductance, melting point and room temperature magnetic moment measurements. The metal complexes were mostly non-electrolyte in DMSO with molar conductance values in the range 19.70 - 46.80 Ω-1cm2mol-1. Nicotinamide and Aspirin behaved as bidentate, coordinating to the metal ion through their carbonyl oxygen and pyridinyl nitrogen atoms respectively, as corroborated by infrared spectroscopy measurement. Electronic spectra indicated that all the metal complexes adopted octahedral geometry and magnetic data revealed that the Mn(II) and Ni(II) complexes were probably dimeric, while the remaining metal complexes were monomeric, diamagnetic or paramagnetic. In addition, the antioxidant study revealed that the drugs, Aspirin and Nicotinamide (Vitamin B3), and their mixed metal complexes had higher antioxidant activity than Ascorbic acid, the positive standard, thus confirming their potentials as anticancer agents in-vitro.