Long-term weight fluctuation was significantly associated with an increased risk of metabolic syndrome (OR 3.22 for highest vs lowest quartile) among normal-weight Japanese men (BMI <25 kg/m2).
Cross-Sectional (n=644)
No
Does long-term weight fluctuation increase the risk of metabolic syndrome in middle-aged Japanese men?
Long-term weight fluctuation is associated with an increased risk of metabolic syndrome, particularly in normal-weight individuals, suggesting that maintaining a stable weight is important for cardiovascular prevention.
Odds Ratio: 3.22 (95% CI 0.84–12.31)
Absolute Event Rate: 10.5% vs 2.4%
p-value: p=0.034
BACKGROUND: The relation between weight fluctuation and the risk of cardiovascular disease (CVD) is fairly consistent, although the physiologic basis for the relationship is uncertain. In the present study the association between long-term weight fluctuation and the development of metabolic syndrome (MS), a potent CVD risk factor, was investigated. METHODS AND RESULTS: A cross-sectional study of 664 Japanese men aged 40-49 years was conducted. The root mean square error around the slope of weight on age (weight - RMSE) was calculated by a simple linear regression model, in which the subject's actual weights at ages 20, 25, 30 years and 5 years prior to the study, as well as current weight, were dependent variables against the subject's age as the independent variable. Weight-RMSE was significantly and positively associated with the prevalence of each MS components (high blood pressure, hypertriglyceridemia, low-high density lipoprotein-cholesterol, high fasting glucose, and obesity). Such associations, as well as clustering of the MS component together with RMSE increase, were apparent among subjects with body mass index (BMI) or=25 kg/m2). CONCLUSIONS: Development of MS possibly explains the risk of CVD not only in overweight or obese persons, but also in normal-weight persons with large weight fluctuation.
Zhang et al. (Mon,) conducted a cross-sectional in Metabolic Syndrome (n=644). Long-term weight fluctuation (highest quartile of weight-RMSE) vs. Lowest quartile of weight fluctuation was evaluated on Metabolic syndrome (≥3 components) in men with BMI <25 kg/m2 (OR 3.22, 95% CI 0.84-12.31, p=0.034). Long-term weight fluctuation was significantly associated with an increased risk of metabolic syndrome (OR 3.22 for highest vs lowest quartile) among normal-weight Japanese men (BMI <25 kg/m2).