Data from positron emission tomography studies support the clinical observation that cerebral activity and thyroid status are related in patients with mood disorders.In addition, alterations in the central nervous system metabolism of thyroid hormones might be related to the mechanisms of action of antidepressant and mood stabilizer treatments. Finally, thyrotropin-releasing hormone might have important effects on mood.
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Marangell et al. (1998) studied this question.
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