Key result
Female patients with acute coronary syndrome had a substantially higher inhospital mortality rate (7.9% vs. 5.4%) and less frequently underwent coronary interventions (35% vs. 47%) compared to male patients.
Why the study?
Sex differences in patients with ACS remain a matter of debate.
Are there sex-specific differences in the incidence, treatment, and inhospital mortality of patients with acute coronary syndrome?
Cohort (n=3,797,546)
Yes
Are there sex-specific differences in the incidence, treatment, and inhospital mortality of patients with acute coronary syndrome?
Answers are grounded in this paper and cite their sources.
Women with ACS experience lower rates of invasive coronary procedures and higher inhospital mortality compared to men, highlighting significant sex disparities in care and outcomes.
Sex differences in patients with acute coronary syndrome (ACS) are a matter of debate. We investigated sex-specific differences in the incidence, outcomes, and related interventions in patients diagnosed with ACS in Germany over the past decade. All ACS cases from 2005 to 2015 were collected. Procedures and inhospital mortality were assessed by sex. Age-adjusted incidence rates were calculated. In total, 1,366,045 females and 2,431,501 males presenting with ACS were recorded. Females were older than males (73.1 vs. 66.4 years of age), had a longer mean hospital stay (7.7 vs. 6.9 days), and less frequently underwent coronary angiographies (55% vs. 66%) and coronary interventions (35% vs. 47%). The age-adjusted incidence rate of ACS was lower in females than in males, and decreased in both sexes from 2005 to 2015. The age-adjusted inhospital mortality rate was substantially higher in females than in males, but decreased in both sexes over time (in females, from 87 to 71 cases per 1000 person years; in males, from 57 to 51 cases per 1000 person years). In conclusion, we reported sex differences in the incidence, treatment, and outcomes of ACS patients in Germany within the past decade. Women had a substantially higher mortality rate and lower rate of coronary interventions.
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Neumann et al. (2020) conducted a cohort in Acute Coronary Syndrome (ACS) (n=3,797,546). Female sex vs. Male sex was evaluated on Inhospital mortality. Female patients with acute coronary syndrome had a substantially higher inhospital mortality rate (7.9% vs. 5.4%) and less frequently underwent coronary interventions (35% vs. 47%) compared to male patients.
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