Evidence is presented for the facile acid‐hydrolytic cleavage of C ‐terminal N ‐alkylated amino acid residues in peptide acids. A mechanism (defined as “back‐biting”) is proposed in which the process is initiated by a nucleophilic attack of the conjugated base of the terminal acid on the (protonated) preceding cis ‐peptide bond.
No takes yet. Share an insight, caveat, or question.
Auwera et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: