Titanium Tetrachloride in Organic Synthesis [New synthetic methods (21)]

Titanium tetrachloride can accelerate numerous organic reactions. Valuable syntheses of, e.g. , allyl sulfides, amides, enamines, and ketones are based upon transformations of functional groups with TiCl 4 . Particular mention should also be made of carbon‐carbon linkage with TiCl 4 which permits the synthesis of hydroxy ketones and carbonyl compounds of the Michael adduct type. TiCl 4 reduced in situ is suitable for the reduction of chloroarenes or the linkage of two aldehyde molecules to give an alkene.