Key result
Prolonged QTc at pacemaker implantation was a significant risk factor for developing dilated cardiomyopathy in infants with congenital complete atrioventricular block (HR 23; 95% CI 4-128; P<0.001).
Why the study?
What are the risk factors for developing early dilated cardiomyopathy in neonates with congenital complete atrioventricular block treated with permanent RV pacing?
Population
25 neonates/infants with congenital complete atrioventricular block without other congenital heart defects…
Design
Cohort
Follow-up
median 4 (0.3-16) years
Authors
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May guide intensified surveillance in high-risk neonates; hypothesis-generating for preventive strategies.
Cohort (n=25)
No
What are the risk factors for developing early dilated cardiomyopathy in neonates with congenital complete atrioventricular block treated with permanent RV pacing?
Hazard Ratio: 23 (95% CI 4–128)
p-value: p=<0.001
Prolonged QTc at implantation is a major risk factor for the development of early dilated cardiomyopathy in neonates with congenital complete AV block undergoing right ventricular pacing.
Silvetti et al. (2010) conducted a cohort in Congenital complete atrioventricular block (n=25). Prolonged QTc at implantation vs. Normal QTc was evaluated on Dilated cardiomyopathy (DCM) (HR 23, 95% CI 4-128, p=<0.001). Prolonged QTc at pacemaker implantation was a significant risk factor for developing dilated cardiomyopathy in infants with congenital complete atrioventricular block (HR 23; 95% CI 4-128; P<0.001).
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