CRISPR/Cas systems show promise for disease treatment, but their clinical implementation is currently hindered by delivery system inefficiencies and off-target effects.
This review summarizes the current state, delivery challenges, and clinical hurdles of CRISPR/Cas systems for disease treatment.
applications of CRISPR systems. The efficiency of CRISPR systems in disease treatment is directly influenced by the performance of the delivery system. Additionally, concerns such as off-target effects present crucial hurdles in the clinical implementation of CRISPR systems. This review provides a comprehensive overview of the development of CRISPR systems, vector technologies, and their applications in disease treatment, while also addressing the challenges encountered in clinical settings. Furthermore, future research directions are outlined to pave the way for advancements in CRISPR-based therapies.
Xu et al. (Sat,) conducted a review in Disease. CRISPR/Cas systems was evaluated. CRISPR/Cas systems show promise for disease treatment, but their clinical implementation is currently hindered by delivery system inefficiencies and off-target effects.