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Optimal antigen excess accelerates immunity and sensitization in models; leaves open translation to human hypersensitivity.
Summary Mice injected intravenously with BSA and rabbit anti-BSA serum in antigen excess show an accelerated immune response to the antigen. This immune response is related to the ratio of BSA to anti-BSA used in the initial injection. The optimal combination of BSA and anti-BSA is in slight antigen excess. Anaphylactic sensitization parallels the accelerated immune response in time of onset. This response to BSA is not related to bacterial contamination.
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Terres et al. (1961) studied this question.
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