Key result
Cryoelectron microscopy revealed that all three poliovirus serotypes use a common mechanism for cell entry by binding to the CD155 receptor in similar orientations within the viral canyon.
Structural analysis reveals that all three poliovirus serotypes use a common mechanism for cell entry via the CD155 receptor, with specific interactions at the viral canyon rim initiating uncoating.
No takes yet. Share an insight, caveat, or question.
May enable serotype-independent countermeasures; extends structural insights on CD155 engagement to all poliovirus serotypes.
He et al. (2003) studied Poliovirus infection. Cryoelectron microscopy revealed that all three poliovirus serotypes use a common mechanism for cell entry by binding to the CD155 receptor in similar orientations within the viral canyon.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: