Key result
An autopsy of an elderly man with severe von Willebrand's disease revealed extensive atherosclerotic lesions, suggesting abnormal platelet adhesion may not protect against atherosclerosis.
Why the study?
Does severe von Willebrand's disease protect against the development of atherosclerosis?
Case Report (n=1)
Does severe von Willebrand's disease protect against the development of atherosclerosis?
The finding of extensive atherosclerosis in a patient with severe von Willebrand's disease suggests that abnormal platelet adhesion does not necessarily protect against atherogenesis.
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Does not support atheroprotection by severe vWD; hypothesis-generating and leaves open platelet adhesion's role in atherosclerosis.
Kernoff et al. (1981) conducted a case report in Severe von Willebrand's disease (n=1). Severe von Willebrand's disease was evaluated on Atherosclerotic lesions at autopsy. An autopsy of an elderly man with severe von Willebrand's disease revealed extensive atherosclerotic lesions, suggesting abnormal platelet adhesion may not protect against atherosclerosis.
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