The infusion of 10% solutions of glucose, galactose and fructose into normal subjects caused significant increases in the excretion ratios of phosphate and alpha-amino nitrogen. The infusions of 10% xylose solutions at the same rate caused similar hemodynamic and osmotic alterations, but no changes in the excretion of these substances. Column chromatographic analysis revealed that glucose infusion impaired the reabsorption of numerous amino acids. The excretion ratios of phosphate and alpha-amino nitrogen could not be correlated with the plasma hexose concentrations or rate of hexose excretion, but other data are cited to support the thesis that the observed inhibition of phosphate and amino acid reabsorption is due to a toxic effect of the hexoses or their metabolites on the renal tubular transport system.
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Fox et al. (1964) studied this question.